Blar i forfatter "Toft, Helge Prytz"

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    • Circulating cytokine levels in the treatment of comorbid anxiety disorders 

      Johnson, Sverre Urnes; Hoffart, Asle; Tilden, Terje; Toft, Helge Prytz; Neupane, Sudan; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-28)
      Psychotherapy research aims to investigate predictors and moderators of treatment outcome, but there are few consistent findings. This study aimed to investigate cytokines in patients undergoing treatment for anxiety disorders and whether the level of cytokines moderated the treatment outcome. Thirty-seven patients with comorbid and treatment-resistant anxiety disorders were investigated using ...

    • Cytokine concentrations are related to level of mental distress in inpatients not using anti-inflammatory drugs 

      Toft, Helge Prytz; Lien, Lars; Neupane, Sudan Prasad; Abebe, Dawit Shawel; Tilden, Terje; Wampold, Bruce E.; Bramness, Jørgen G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-02)
      <p><i>Objective - </i>Cross-sectional data show elevated levels of circulating cytokines in psychiatric patients. The literature is divided concerning anti-inflammatory drugs’ ability to relieve symptoms, questioning a causal link between inflammatory pathways and psychiatric conditions. We hypothesised that the development of circulating cytokine levels is related to mental distress, and that this ...

    • The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment 

      Toft, Helge Prytz; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Tilden, Terje; Wampold, Bruce E.; Lien, Lars (Journal article; Peer reviewed, 2018-04-10)
      <b>Background</b><br> Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol ...

    • History of Delirium Tremens in AUD Patients in Treatment: Relationship to AUD Severity and Other Factors 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Toft, Helge Prytz; Lien, Lars; Bolstad, Ingeborg (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-13)
      Introduction: Delirium tremens (DT) occurs after stopping prolonged, high alcohol intake and may be life-threatening if untreated. We need to know about clinical correlates of DT in order to provide the best clinical care.<p> <p>Methods: At admission to inpatient treatment a cohort of 114 alcohol use disorder (AUD) patients were interviewed and examined concerning psychiatric diagnosis and symptoms, ...

    • PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress 

      Toft, Helge Prytz; Bramness, Jørgen Gustav; Lien, Lars; Abebe, Dawit Shawel; Wampold, Bruce E.; Tilden, Terje; Hestad, Knut; Neupane, Sudan Prasad (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
      <p><i>Background</i>: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric treatment. We aimed to explore circulating cytokines and assess psychiatric symptom severity scores during 12 weeks of inpatient psychiatric treatment.</p> <p><i>Methods</i>: ...